Table 5 TAC and MMF dosing experiments
From: Effect of immunosuppression on hESC-derived retina organoids in vitro and in vivo
TAC dosing | |||||
|---|---|---|---|---|---|
Weight range 70–300 g* | |||||
0 Tx | 10Â mg 90-day TAC pellet | 20Â mg 90-day TAC pellet | 20Â mg 60-day TAC pellet | 30Â mg 90-day TAC pellet | 30Â mg 60-day TAC pellet |
|  | 0.37–1.59 mg/kg/day | 0.74–3.17 mg/kg/day | 1.11–4.76 mg/kg/day | 1.11–4.76 mg/kg/day | 1.67–7.14 mg/kg/day |
MMF dosing | |||||
|---|---|---|---|---|---|
Rat weight (g) | Consumption rate %BW | Consumption/day in (g) | 100Â mg/kg | 150Â mg/kg | 300Â mg/kg |
100 | 8 | 8 | 8 g food @8 g(0.1)kg = 0.08 kg food × (100 mg) = 8 mg/kg dose (0.1 kg) = 0.8 mg/kg /day | 8 g food @ (0.1)kg = 0.08 kg food × (150 mg) = 12 mg/kg dose (0.1 kg) = 1.2 mg/kg/day | 8 g food @(0.1)kg = 0.08 kg food × (300 mg) = 24 mg/kg dose (0.1 kg) = 3 mg/kg/day |
200 | 6 | 12 |  = 2.4 mg/kg/day |  = 3.6 mg/kg/day |  = 7.2 mg/kg /day |
300 | 5 | 15 |  = 4.5 mg/kg /day |  = 6.75 mg/kg/day |  = 13.5 mg/kg /day |
Dosing regimens | ||||||||
|---|---|---|---|---|---|---|---|---|
| Â | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
IS Tx | 0 Tx | 10 mg 90-day TAC | 100 mg/kg MMF | 10 mg 90-day TAC 150 mg/kg MMF | 20 mg 90-day TAC | 20 mg day TAC 150 mg/kg MMF | 20 mg 60-day TAC 300 mg/kg MMF | 30 mg 60-day TAC 300 mg/kg MMF |
Dose daily in mg/kg | 0 | 0.37–1.59 mg/kg/day | 0.8–2.4 mg/kg/day | TAC 0.37–1.59 mg/kg/day MMF 1.2–6.75 mg/kg/day | TAC 0.74–3.17 mg/kg/day | TAC 0.74–3.17 mg/kg/day MMF 1.2–6.75 mg/kg/day | TAC 1.11–4.76 mg/kg/day MMF 3–13.5 mg/kg/day | TAC 1.67–7.14 mg/kg/day MMF 3–13.5 mg/kg/day |