Fig. 2
From: Lyophilized MSC-EVs attenuates COVID-19 pathogenesis by regulating the JAK/STAT pathway
A gene expression profiles of IL-8. B Effect of MSCs-EVs administration on protein levels of IL6, JAK1, JAK2, phosphorylated STAT3, TLR4, NF-κB, TGF-β and TNF-α in lung tissues from different experimental groups as detected by western blot. Data were expressed as mean ± SE. ****significant compared to Control at p < 0.0001, and # significant compared to COVID- 19 group at p < 0.05, #### at p < 0.0001. c Representative photomicrographs from Ang 1–7 immune stained lung sections showing a) Control group: negative immune reaction. b) Covid group: with intense immune reaction in consolidated lung tissue (curved arrow). c) MSCs-EVs group: negative immune reaction. d) Graph showing Allred score for Ang1-7 expression. Data are expressed as mean ± SEM.***p < 0.001 versus control, p < 0.001 versus COVID group. Allred index (0–1 = negative, 2–3 = mild, 4–6 = moderate, and 7–8 = strongly positive)