Fig. 3
From: Lyophilized MSC-EVs attenuates COVID-19 pathogenesis by regulating the JAK/STAT pathway
I Representative photomicrographs from STAT1 &STAT3 immune stained lung sections showing a Control group: with a moderate immune reaction (arrow). b Covid group: with weak immune reaction in consolidated lung tissue (arrowhead). c MSCs-EVs group: with a moderate immune reaction (arrow). d Graph showing Allred score for STAT1 expression. e Control group: with a moderate immune reaction (arrow). f Covid group: with strong immune reaction in consolidated lung tissue (arrowhead). g MSCs-EVs group: with a moderate immune reaction (arrow). h Graph showing Allred score for STAT3 expression Data are expressed as mean ± SEM.***p < 0.001 versus control, ###p < 0.001 versus Covid group. Allred index (0–1 = negative, 2–3 = mild, 4–6 = moderate, and 7–8 = strongly positive). II Effect of MSCs-EVs administration on gene expression profiles of A INFR1, B: INFR2 and C IRF-3. Data were expressed as mean ± SE. ** significant compared to Control at p < 0.01, ****significant at p < 0.0001, and # significant compared to COVID- 19 group at p < 0.05, #### at p < 0.0001