Harnessing stem cell therapeutics in LPS-induced animal models: mechanisms, efficacies, and future directions

Table 2 Disease models induced by LPS but not treated with stem cells to date

Animal model	Study subject	LPS delivery route	Model details and timing of administration	Year	References
Preterm labour	Female BALB/c mice	intraperitoneal injections	two injections of 50 μg/kg LPS, 3 h apart	2020	[111]
Preterm labour	Female BALB/c mice	intraperitoneal injections	two injections of 0.4 mg/kg LPS	2016	[112]
Hemophagocytic Lymphohistiocytosis	Male SAMP1/TA-1 mice	intravenous injection	three injections of 25 μg LPS at weekly intervals	2019	[113]
Orchitis	Male C57BL/10 mice	intraperitoneal injections	100 μg of LPS in 1 ml of sterile PBS	2014	[114]
Orchitis	Male adult sheep	intra-testicular injection	10 µg of LPS in 50 µL of saline	2020	[115]
Nasal Polyp	Male C57BL/6 J mice	instilled in each nostril	10 μL of LPS in each nostril for a total of 100 μg	2023	[17]

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