Fig. 2

OSDI, SIT, CFS score, TMH, and NIBUT at baseline, T-week 1, T-week 2 and follow-up period in the NSDE and SSDE groups. Clinical outcomes were measured in 9 patients with NSDE and 5 patients with SSDE who completed treatment and follow-up visits (Except for OSDI, all other items are assessed for both eyes. Data after MSC eye drops treatment from T-week1/2 and F-week1/2/3/4 were compared with baseline data (baseline). A OSDI score. B SIT value. C CFS score. D TMH value. E The scale of TMH. F Representative images of tear meniscus in the NSDE and SSDE groups pre- and post-treatment. G First NIBUT value. H Average NIBUT value. I The scale of Average NIBUT. J The differences in the variations of primary efficacy indicators between the two groups (NSDE, SSDE) following MSC eye drops treatment. Data are presented as the Mean ± SEM for A, B, C, D, G, H and I, while E and I are depicted on a scale from 1 to 4. The criteria for this scale are outlined in Table S2. nsP > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001. Abbreviations: NSDE = non-Sjögren's syndrome dry eye, SSDE = Sjögren's syndrome dry eye, OSDI = Ocular Surface Disease Index, TMH = tear meniscus height, NIBUT = non-invasive break-up time, SIT = Schirmer I test, CFS = corneal fluorescein stain