Fig. 8

Specific miRNAs in Exos, including miR-27b-3p, miR-145-5p, and miR-16-5p, inhibit Smad2 phosphorylation and exert anti-fibrotic effects. (a) Dual luciferase reporter assay. (b) Western blot detection of p-Smad2 in HESCs. (c) Statistical analysis of Western blot. (d) RT-qPCR analysis of miR-27b-3p, miR-145-5p, and miR-16-5p expression in uterine tissues from rats. (e) Western blot detection of smad2 and smad3 expression in uterine tissues of rats. (f) Statistical analysis of Western blot