Fig. 6

DSUP modified MSCs significantly reduced the incidence of hematopoietic failure in irradiated mice. A Schematic diagram of 4.5 Gy X-ray radiation damage assay in mice model after infusion of DSUP modified MSCs. B Hemogram change curve of CON / DSUP group mice after 4.5 Gy radiation (including RBC, WBC, and PLTs). Mean ± SEM, n = 12, ns: no significant difference, by two-way ANOVA. C Survival rate curve of CON / DSUP group mice after radiation, n = 12, *p = 0.026, analyzed by Log-rank test. D BM pathological section of femoral shaft in CON / DSUP group mice after radiation, the BM collection time of each mice after radiation was marked above each image. The red collection time represents the death time of mice after radiation, while the green collection time (D20) represents the sacrifice time of surviving mice after 20 days of radiation. The mean of BM karyocyte cells percent was marked in the bottom left corner of the image, bar = 200 μm. E BM karyocyte cells percent of CON / DSUP group irradiated mice at collection time point of Figure D. The difference between the two groups dead mice cannot be statistically analyzed due to the too small sample size of the DSUP group dead mouse, while the difference between the two groups surviving mice was analyzed, Mean ± SEM, *p < 0.05, by Student’s t-test