Fig. 8

The radiation protective effect of DSUP-modified mouse MSCs in immuno-healthy C57BL/6 mice. A Morphological images and flow cytometry results of mouse BM-MSCs, scale bar = 100 μm. The flow cytometry results of mouse MSCs typical surface markers (mCD105, mCD44, mSca1, CD29 were positive markers, and mCD34, mCD45, mCD48, mCD31, and mCD11b were negative markers). B Survival rate curve of C57BL/6 mice pre infused with edited MSCs and then treated with 6 / 7 Gy X-ray radiation (CON: n = 15; DSUP: n = 16), *p < 0.05, median survival period and survival rates were analyzed by Log-rank test. C–D Hemogram change curve of two group C57BL/6 mice after 6 Gy (C) and 7 Gy (D) X-ray radiation. Mean ± SEM, *p < 0.01, ns: no significant difference, by two-way ANOVA