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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Mesenchymal stem cell-derived exosomes: an emerging therapeutic strategy for hepatic ischemia-reperfusion injury

Fig. 4

Exosomes secreted by BMSCs, modified with HO-1, deliver miR-124-3p. miR-124-3p targets STEAP3, reducing the conversion of Fe³⁺ to Fe²⁺ and promoting the transport of Fe²⁺ via DMT1, thereby regulating the process of ferroptosis. In the Fenton reaction, Fe²⁺ induces lipid peroxidation, increases lipid ROS, and activates ferroptosis, a process that is suppressed by the antioxidant action of GPX4. Additionally, miR-25-3p in the exosomes can inhibit PTEN, thereby regulating the p53 signaling pathway and reducing cell apoptosis

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Stem Cell Research & Therapy

ISSN: 1757-6512