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Table 1 Summary of clinical studies of mesenchymal stem cells therapy for acute-on-chronic liver failure

From: Efficacy and safety of mesenchymal stem cell therapy in acute on chronic liver failure: a systematic review and meta-analysis of randomized controlled clinical trials

Included studies

Country

Design

Age(year)

Patients

Cell type

Total dose/kg body weight (average 50kg/person)

Administration route

Follow up

Main outcome measures

Cause of ACLF

Shi et al (2012)

China

RCT

EG: 24 ± 8.75 CG: 45 ± 9

EG: 24 CG: 19

UC-MSCs

0.5×107cells/kg

vein of the arm

1,2,4,8,12,24,36, 48weeks

ALT,TBIL,ALB,CHE,PTA,MELD score

HBV

Xu et al (2019)

China

RCT

EG: 40.67 ± 9.89 CG: 44.97 ± 11.83

EG: 30 CG: 30

UC-MSCs

1×106cells/kg

intravenous

30,60,90,180weeks

ALT,TBIL,ALB,MELD score

HBV

Li et al (2016)

China

RCT

EG: 40.67 ± 9.89 CG: 44.97 ± 11.83

EG: 11 CG: 34

UC-MSCs

1×108cells/kg

intravenous

4–24 months

HCC incidence, ALT,TBIL,ALB,MELD score

HBV

Lin et al (2013)

China

RCT

EG: 40.04 ± 9.94 CG: 42.78 ± 8.4

EG: 56 CG: 54

UC-MSCs

1.0–10×108cells/kg

intravenous

1, 2, 3, 4, 8, 12 and 24 weeks

ALT,TBIL,ALB,MELD score

HBV

Peng et al (2011)

China

RCT

EG: 42.19 ± 9.94 CG: 42.78 ± 8.4

EG: 53 CG: 105

BM-MSCs

UK

hepatic artery

1,2,3,4,12,

24,36,48 weeks

ALT,ALB,TBIL,PT,MELD score

HBV

Schacher et al (2021)

Brazil

RCT

EG: 55.8 ± 12.8 CG: 53.4 ± 14.4

EG: 4 CG: 5

BM-MSCs

1×106cells/kg

intravenous

UK

ALT,TBIL,ALB,PT,CRP

HBV

Jia et al (2020)

China

non-RCT

16–60

513

UC-MSCs

1×106cells/kg

intravenous

1, 4, 12, 24

ALT,TBIL,AST

HBV

  1. EG: experimental Croup; CG: control Croup; ACLF: Acute-on-chronic liver failure; RCT: randomized controlled trial; UK: unknown; BM-MSCs: bone marrow mesenchymal stem cells; UC-MSCs: umbilical cord mesenchymal stem cells; MELD: model for end-stage liver disease; ALT: alanine aminotransferase; ALB: albumin; AST: aspartate aminotransferase; TBIL: total bilirubin; INR: international normalized ratio; PT: prothrombin time; HBV: hepatitis B virus