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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Extracellular vesicles from hiPSC-derived NSCs protect human neurons against Aβ-42 oligomers induced neurodegeneration, mitochondrial dysfunction and tau phosphorylation

Fig. 5

The effects of adding extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSC-EVs) into iNeurons cultures on Aβ-42 oligomers (Aβ-42o) -induced oxidative stress markers, total ROS and mitochondria-generated superoxide. The bar charts A-D compare the concentrations of malondialdehyde (MDA, A, C) and protein carbonyls (B, D) in Aβ-42o exposed cultures of iNeurons 1 (A-B) and iNeurons 2 (C-D) treated with different concentrations of hiPSC-NSC-EVs. The bar charts (E-H) compare the relative gene expression of iNos (E, G) and Cox2 (F, H) in Aβ-42o exposed cultures of iNeurons 1 (E-F) and iNeurons 2 (G-H) treated with different concentrations of hiPSC-NSC-EVs. The bar charts (I-J) compare the fluorescence intensity values for total ROS (I) and mitochondria-generated superoxide measured via MitoSOX (J) in iNeurons 1 cultures across study groups. The experiments comprised measurements from 3 biological replicates/group

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Stem Cell Research & Therapy

ISSN: 1757-6512