Skip to main content
Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Extracellular vesicles from hiPSC-derived NSCs protect human neurons against Aβ-42 oligomers induced neurodegeneration, mitochondrial dysfunction and tau phosphorylation

Fig. 6

The effects of adding extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSC-EVs) into iNeurons cultures on Aβ-42 oligomers (Aβ-42o)-induced pro- and anti-apoptotic gene and protein expression. The bar charts (A-E) and (C-G) compare the relative expression of genes Bad (A, C), Bax (B, D), and Bcl2 (E, G) in Aβ-42o exposed cultures of iNeurons 1 (A-B and E) and iNeurons 2 (C-D and G) treated with different concentrations of hiPSC-NSC-EVs. The bar charts F, H, I, and J compare the protein concentrations of BAD (F, H) and BCL2 (I, J) in Aβ-42o exposed cultures of iNeurons 1 (F, I) and iNeurons 2 (H, J) treated with different concentrations of hiPSC-NSC-EVs. The experiments comprised measurements from 3 biological replicates/group

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512