Skip to main content
Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Extracellular vesicles from hiPSC-derived NSCs protect human neurons against Aβ-42 oligomers induced neurodegeneration, mitochondrial dysfunction and tau phosphorylation

Fig. 8

The effects of adding extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSC-EVs) into iNeurons cultures on Aβ-42 oligomers (Aβ-42o)-induced mitochondrial depletion. Figures (A-I) show representative images of TOM20 + structures (red, visualizing mitochondria) in Map-2 + neurons (green) in cultures from a control group (A, D, G), Aβ-42o treated group (B, E, H), or Aβ-42o and 6 × 109 hiPSC-NSC-EVs treated group (C, F, I). The bar charts compare the area fraction (AF) TOM20 + mitochondria measured by Image J (J) across control, Aβ-42o exposed, and Aβ-42o and 6 × 109 hiPSC-NSC-EVs treated groups. Scale bar, 100 μm. The experiments comprised measurements from 3 biological replicates/group

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512