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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Footprint-free induced pluripotent stem cells can be successfully differentiated into mesenchymal stromal cells in the feline model

Fig. 4

In vivo differentiation assay. (A). Macroscopic images of immunodeficient NOD-scid gamma (NSG) mice at week 8 post injection of feline iPSCs (i) and dissected mass (ii). (B). Higher magnification of square region in i highlighting a region of differentiation into cartilage (arrowhead) and bone (arrow) surrounded by germ cell tumor-like cells (asterisk). Scale bar in i = 2 mm and ii = 200 mm. H&E stain. (C). Quantitative polymerase chain reaction (qPCR) analysis of endogenously expressed feline differentiation markers, human transcription factors hKOS, hKLF4, hc-MYC, and SeV in dissected mass

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Stem Cell Research & Therapy

ISSN: 1757-6512