Fig. 7
Protective effects of iMSCs on alveolar bone loss in periodontitis mice. A Micro-CT reconstruction images show the morphological changes of the jawbone in healthy, periodontitis, and iMSCs treatment groups of mice. B Quantitative Micro-CT analysis, including measurements of CEJ-AB distance, BMD, and BV/TV. C Quantitative results of the TRAP-positive area surrounding the alveolar bone in mice. D TRAP staining revealing osteoclast activity around the alveolar bone in mice. Scale bars: 100 μm (upper panels) and 50 μm (lower panels). E HE staining demonstrating histological changes in periodontal tissues of the healthy, periodontitis, and iMSCs-treated groups. Scale bars: 100 μm (upper panels) and 50 μm (lower panels). *P < 0.05, **P < 0.01, ***P < 0.001; ns, not significant (P > 0.05)