Table 3 Diagnostic role of small extracellular vesicles in cancer diseases
From: Small extracellular vesicles: the origins, current status, future prospects, and applications
Detecting disease | Biomarker | Source | Patient expression | Diagnostic yield | Ref. |
|---|---|---|---|---|---|
Lung cancer | circRAPGEF5 | Serum | Raise | AUC = 0.847, Sensitivity:64.90%, Specificity:95.60% | [118] |
circ__0048856 | Serum | Raise | AUC = 0.943. Sensitivity:0.880 Specificity:0.800 | [119] | |
miR-200b-3p miR-3124-5p miR-92b-5p | Serum | miR-92b-5p ↓ miR-200b-3p↑ miR-3124-5p ↑ | AUC = 0.93 | [120] | |
miR-1290 miR-29c-3p | Plasma | miR-1290↑ miR-29c-3p↓ | AUC1 = 0.934 AUC2 = 0.868 | [121] | |
Gastric cancer | miR-10401-3p miR-1255b-5p miR-6736-5p | Serum | Decline | AUC1 = 0.8333, AUC2 = 0.8316 AUC3 = 0.8142 | [122] |
miR-31 miR-192 miR-375 | Plasma | Raise | AUC1 = 0.734 AUC2 = 0.812 AUC3 = 0.745 | [123] | |
Liver cancer | miR-10b-5p | Serum | Raise | AUC = 0.934, Sensitivity:90.7%; Specificity:75.0%. | [124] |
Breast cancer | miR-18a-3p | Serum | Raise | AUC = 0.83 | [125] |
miR-1246 | Plasma | Raise | Sensitivity:97.30% Specificity:93.94% | [126] | |
H19 | Serum | Raise | Sensitivity:87.0% Specificity:70.6% | [127] | |
annexin A2 | Serum | Raise | AUC = 1.00 | [128] | |
Colorectal cancer | miR-3937 | Plasma | Raise | AUC = 0.827 | [129] |
miR-874 | Serum | Decline | AUC = 0.818 Sensitivity:80.8% Specificity:78.6% | [130] | |
circGAPVD1 | Plasma | Raise | AUC = 0.7662, Sensitivity:75.64% Specificity:71.79% | [131] |