Small extracellular vesicles: the origins, current status, future prospects, and applications

Table 4 Diagnostic role of small extracellular vesicles in non-cancer diseases

Affiliation system	Detecting disease	Biomarker	Source	Patient expression	Diagnostic yield	Ref.
Respiratory system	Allergic asthma	miR-223 miR-142a	Alveolar lavage fluid	miR-223↑ miR-142a↑	/	[132]
Nervous system	Parkinson’s disease	miR-23b-3p	Plasma	Raise	AUC = 0.8086	[133]
	Parkinson’s disease	miR-223-3p	Serum	Raise	Sensitivity:71.1% Specificity:79.9% AUC = 0.771	[134]
	Senile dementia	miR-135a	Serum	Raise	/	[135]
	Senile dementia	Amyloid β-protein and miR-384	Plasma	Raise	AUC1 = 0.969 AUC2 = 0.906	[136]
Urinary system	IgA Kidney Disease	lncRNA G21551	Plasma	Decline	/	[137]
	IgA Kidney Disease	miR-451a	Urine	Raise	AUC = 0.805	[138]
	Diabetic nephropathy	Circ_0008529	Urine	Raise	Sensitivity:70.21% Specificity:86.67%	[139]
Endocrine system	Type 1 diabetes	miR-146a-5p miR-223-3p miR-21-5p	Plasma	Raise	AUC1 = 0.978 AUC2 = 0.96 AUC3 = 0.809	[140]

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