Fig. 1

Rab27a knockout inhibits exosome secretion to attenuate renal fibrosis. A Rab27a knockout. B, C Representative western blots (B) and quantitative data (C) of CD63, Hsp70, and TSG101 in Rab27a knockout kidneys after modeling (n = 6). *p < 0.05 versus Sham, #p < 0.05 versus Model. D, E Changes in Scr and BUN levels in mice in each group. F, G Representative western blots (F) and quantitative data (G) of Col-III, α-SMA, FN, and E-cad in Rab27a knockout kidneys after modeling (n = 6). *p < 0.05 versus Sham, #p < 0.05 versus Model. H, I Representative immunofluorescence micrographs (H) and quantitative data (I) showing Col-III, α-SMA, FN, and E-cad expression (n = 6). Scale bars = 50 μm. *p < 0.05 versus Sham, #p < 0.05 versus Model. J, K H&E and Masson’s staining. Representative micrographs (J) and quantitative data (K) are presented (n = 6). Scale bars = 50 μm. *p < 0.05 versus Sham, #p < 0.05 versus Model