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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Renal tubular epithelial cell-derived Exosomal miR-330-3p plays a key role in fibroblast activation and renal fibrosis by regulating CREBBP

Fig. 6

RTEC-derived exosome miR-330-3p mediates fibroblast activation via CREBBP. A Experimental design. B CREBBP mRNA level after si-CREBBP treatment. ns, no significant difference versus the Ctrl, *p < 0.05 versus the Ctrl. C, D Representative western blots (C) and quantitative data (D) of Col-III, FN, FSP1, and PCNA in NRK-49 F cells after stimulation with NRK-52E–delivered exosomes. *p < 0.05 versus Sham, #p < 0.05 versus UA-Exo. â–³p < 0.05 versus UA-Exo + si-CREBBP. E, F Representative immunofluorescence micrographs (E) and quantitative data (F) show Col-III and FN expression in NRK-49 F cells after stimulation with NRK-52E–delivered exosomes. Scale bars = 50 Î¼m. *p < 0.05 versus Sham, #p < 0.05 versus UA-Exo. â–³p < 0.05 versus UA-Exo + si-CREBBP. G, H Representative western blots (G) and quantitative data (H) of CREBBP in NRK-49 F cells after stimulation with NRK-52E–delivered exosomes. *p < 0.05 versus Sham, #p < 0.05 versus UA-Exo. â–³p < 0.05 versus UA-Exo + si-CREBBP. I CREBBP mRNA levels in NRK-49 F cells after stimulation with NRK-52E–delivered exosomes. *p < 0.05 versus Sham, #p < 0.05 versus UA-Exo. â–³p < 0.05 versus UA-Exo + si-CREBBP. J miR-330-3p level in NRK-49 F cells after stimulation with NRK-52E–delivered exosomes. *p < 0.05 versus Sham, #p < 0.05 versus UA-Exo. â–³p < 0.05 versus UA-Exo + si-CREBBP

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Stem Cell Research & Therapy

ISSN: 1757-6512