Fig. 7

RTEC-derived exosome miR-330-3p exacerbates renal fibrosis by inhibiting CREBBP expression. A, B Representative western blots (A) and quantitative data (B) show Col-III, αSMA, FN, E-cad, FSP1, and PCNA expression in mouse kidneys after tail vein injection (n = 6). *p < 0.05 versus Sham, #p < 0.05 versus Ctrl-Exo, ns, no significant difference versus UA-Exo, ^△p < 0.05 versus UA-Exo. C, D Representative immunofluorescence micrographs (C) and quantitative data (D) show Col-III and FN expression in mouse kidneys after tail vein injection (n = 6). Scale bars = 50 μm. *p < 0.05 versus Sham, #p < 0.05 versus Ctrl-Exo, ns, no significant difference versus UA-Exo, ^△p < 0.05 versus UA-Exo. E, F H&E and Masson’s staining. Representative micrographs (E) and quantitative data (F) are presented (n = 6). Scale bars = 50 μm. *p < 0.05 versus Sham, #p < 0.05 versus Ctrl-Exo, ns, no significant difference versus UA-Exo, ^△p < 0.05 versus UA-Exo. G, H Representative western blots (G) and quantitative data (H) show CREBBP expression in mouse kidneys after tail vein injection (n = 6). *p < 0.05 versus Sham, #p < 0.05 versus Ctrl-Exo, ns, no significant difference versus UA-Exo, ^△p < 0.05 versus UA-Exo. I CREBBP mRNA levels in mouse kidneys after tail vein injection (n = 6). *p < 0.05 versus Sham, #p < 0.05 versus Ctrl-Exo, ns, no significant difference versus UA-Exo, ^△p < 0.05 versus UA-Exo