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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Bone marrow mesenchymal stem cells transport connexin43 via tunneling nanotubes to alleviate isopreterenol-induced myocardial hypertrophy

Fig. 5

Effect of ISO on the localization of Cx43 in TNTs. (A) Immunogold electron micrograph of Cx43 in TNTs. Red triangles marked Cx43 dots were enriched in TNTs between the cells. scale bar: 1 μm and 500 nm. (B) Co-cultured MSCs and CMs were triple labeled with WGA, Cx43, and TnT. Regardless of whether there was ISO, some TNTs contained Cx43 (indicated by arrow heads), and yellow triangles indicate Cx43 in TNTs. TNTs without Cx43 were indicated by arrow tips. N = 4, cale bar: 75 μm. (C) Randomly observe 125 TNTs and quantify the percentage of TNTs containing Cx43 with and without ISO stimulation. N = 4, Data are shown as the mean ± S.E.M. * P < 0.05 vs Ctrl

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Stem Cell Research & Therapy

ISSN: 1757-6512