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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Modulation of senescent Lepr+ skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progression

Fig. 1

Single-cell sequencing revealed that skeletal stem cells underwent cellular senescence in knee osteoarthritis. A Schematic overview of the scRNA-seq workflow. B UMAP plots showing integrated analysis of bone stromal, immune, and synovial cells. The cells are colored according to their clusters. C Proportions of different cell clusters across different sources, including bone stromal cells, bone immune cells, and synovial cells, at different points in the progression of OA. D Stacked bar charts showing the cell cycle status of all samples. E mRNA levels of P21 in all samples. F Scoring of the senescent gene set (SenMayo) in different cell clusters. G, H GO terms enriched in upregulated (G) and downregulated (H) genes

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Stem Cell Research & Therapy

ISSN: 1757-6512