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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Electrophysiological characterisation of intranigral-grafted hiPSC-derived dopaminergic neurons in a mouse model of Parkinson’s disease

Fig. 3

Localisation of in vivo extracellular recordings in mouse brain (A, B) In control mice, 12 electrode tracks were performed every 0.1 mm-step starting from the initiate coordinates (red point in A) and lowered through the substantia nigra pars compacta (SNpc) from − 3.9 mm to -4.4 mm below the brain surface (B). (C, D) In grafted mice, the transplant occupied a larger volume than the SNpc. Consequently, 18 electrode tracks were performed (C), and lowered across a wider range, from − 3.6 to -4.6 mm below the brain surface (D). Abbreviations: λ, lambda; β, bregma; Ant, anterior; SNpc, substantia nigra pars compacta; VTA, ventral tegmental area; MT, medial terminal nucleus

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