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Table 1 Bursting potential

From: Electrophysiological characterisation of intranigral-grafted hiPSC-derived dopaminergic neurons in a mouse model of Parkinson’s disease

SIB

Mean ± SD, n (CV)

Control mDA

grafted mDA

All neurons1

40.23 ± 26.45%

n = 15 (CV = 0.65)

25.69 ± 12.35%ns

n = 4 (CV = 0.48)

Low (≥ 20%)

16.88 ± 3.29%

n = 5 (CV = 0.19)

17.50 ± 8.82%

n = 2 (CV = 0.50)

Intermediate (21–50%)

41.20 ± 7.93%

n = 3 (CV = 0.19)

33.89 ± 10.56%

n = 2 (CV = 0.31)

Highly (> 50%)

72.35 ± 12.51%

n = 7 (CV = 0.17)

None

  1. Bursting potential was assessed using the percentage of spikes in burst (SIB). Classification was performed based on their burst potential, defined by the SIB percentage obtained from 150–180 s of spontaneous activity. Three clusters were defined: low (below 20%), intermediate (21 to 50%) and highly bursty (above 50%). Bursting mode was considered for SIB values over a 1% threshold. Data were expressed as mean ± SD, with n representing the number of bursty neurons; ns indicated not significant difference. 1: Mean analysis and value dispersion between the two dopaminergic populations were performed using an unpaired t-test with Welch’s correction (t, df = 1.58,11.22; p = 0.142) and an F test (F, DFn, Dfd = 4.584,14,3; p = 0.236), respectively
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Stem Cell Research & Therapy

ISSN: 1757-6512