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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Human menstrual blood-derived stem cells secreted ECM1 directly interacts with LRP1α to ameliorate hepatic fibrosis through FoxO1 and mTOR signaling pathway

Fig. 8

Working model. ECM1 in the secretomes of MenSCs directly interacts with LRP1α through N-terminal domain and ligands repeats sequence 4 domain to subsequently suppress AKT/mTOR and activate FoxO1 signaling pathways, which promote the pyrimidine and purine metabolism and the expression of extracellular matrix, thereby inactiving HSC and ultimately attenuating liver fibrosis. Consistently, ECM1-modified MenSCs regulate the transcription of intrinsic cytokine genes to prevent liver fibrosis.

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Stem Cell Research & Therapy

ISSN: 1757-6512