Table 3 m6A methylation modification regulates osteoclastic differentiation
Regulators | Effects on osteoclastogenesis | Mechanism | Species and cells | Ref. |
|---|---|---|---|---|
METTL3↑、YTHDF2 | promotion | Atp6v0d2↓, retention of Traf6 in the nucleus↓ /MAPK↑、NF-kB↑、PI3K-AKT↑ | Mouse RAW264.7 cell lines | [133] |
METTL3↓、YTHDF1 | inhibition | Nos2↑/ iNOS/NO↑/mitochondrial dysfunction↑ | Mouse BMMs | [134] |
METTL3↑ | promotion | EGR1↑/ METTL3↑/ CHI3L1↑ | Mouse BMMs | [135] |
METTL3↑、 ALKBH5↓ | promotion | circ_0008542↑/ miRNA-185-5p↓/ RANK↑ | Mouse RAW264.7 cell lines | [136] |
METTL14↑ | inhibition | GPX4↑ | Mouse BMMs | [137] |
FTO↑ | promotion | phosphorylation and nuclear translocation of NF-κB p65↑/ c-FOS↑、NFATc1↑ | Mouse BMMs and RAW264.7 cell lines | [139] |
FTO↑、YTHDF2 | promotion | CCNA2↑、CDK2↑ | Mouse BMMs | [140] |
YTHDF1↑ | promotion | LPS↑/ YTHDF1↑/ Tnfrsf11a↑/NF-κB↑、MAPK ↑、 PI3K-AKT↑ | Mouse RAW264.7 cell lines | [141] |
YTHDF2↑ | inhibition | NF-κB ↓、MAPK↓ | Mouse RAW264.7 cell lines | [142] |
YTHDC1↑ | inhibition | PTPN6↑ | Mouse BMMs | [143] |