Table 4 m6A methylation modification in OA
Pathological Factors | Regulators | Effects | Mechanism | Species and cells | Ref. |
|---|---|---|---|---|---|
Cartilage injury | METTL3↑ | promotion | IL-1β↑/ METTL3↑/ miR-126-5p↑/ PIK3R2↓/ PI3K/Akt↓ | Human primary chondrocytes | |
METTL3↑ | promotion | lncRNA IGFBP7-OT↑/ IGFBP7↑ | Human primary chondrocytes | [155] | |
METTL3↑、YTHDF2 | promotion | circRNA RERE↓/ miR-195-5p↑/ IRF2BPL↓/β-catenin↑ | Human chondrocytes | [156] | |
METTL3↑、YTHDF1 | inhibition | Bcl2↑ | Mouse chondrocyte line | [157] | |
FTO↑ | inhibition | miR-3591-5p↓/ PRKAA2↑ | Human articular chondrocytes | [158] | |
FTO↑ | inhibition | lncRNA AC008440.5↓/ miR-328-3p↑/ AQP1↓、ANKH↓ | Human primary chondrocytes | [159] | |
ALKBH5↑、 YTHDF2 | inhibition | lncRNA HS3ST3B1-IT1↑/ HS3ST3B1↑ | Human primary chondrocytes | [160] | |
Extracellular matrix degradation | METTL3↑ | promotion | NF-κB↑ | Mouse chondrocyte line | [161] |
METTL3↑ | promotion | lncRNA LINC00680↑/ SIRT1↑ | Human chondrocytes | [162] | |
METTL3↑ | promotion | MMP1↑、MMP3↑、TIMP-1↓、TIMP-2↓ | Human chondrocytes | [163] | |
WTAP↑ | promotion | miR-92b-5p↑/ TIMP4↓ | Human primary chondrocytes | [164] | |
Inflammatory reaction | METTL3↑ | promotion | SOCS2↓/ JAK2/STAT3↑ | Human primary chondrocytes | [167] |
METTL3↓ | inhibition | miR-1208↑/METTL3↓/NLRP3↓ | Human articular chondrocytes | [168] | |
WTAP↑ | promotion | FRZB↓/ Wnt/β-catenin↑ | Human chondrocytes | [169] | |
FTO↑ | inhibition | miR-515-5p↑/ TLR4↓/ MyD88/NF-κB↓ | Human chondrocytes | [170] | |
ALKBH5↑ | promotion | miR-654-3p↓/ TNFRSF9↑/ NF-κB↑ | Human primary chondrocytes | [171] | |
IGF2BP3↑ | promotion | macrophage M1 polarization↑ | Mouse BMDMs | [172] |