Table 6 m⁶A methylation modification in bone tumors

Osteosarcoma

METTL3↑

promotion

ZBTB7C↑, ATAD2↑, HDAC5↑/ miR-142-5p↓/ ARMC8↑

Human osteosarcoma cell

[215,216,217]

METTL3↑、

METTL14↑YTHDF2

inhibition

TRIM7↓/ BRMS1↑

Human osteosarcoma cell

[218]

METTL3↑

promotion

circRNF220↑/ miR-330-5p↓/ Survivin↑

Human osteosarcoma cell

[219]

METTL14↑、IGF2BP2

promotion

MN1↑

Human osteosarcoma cell

[220]

WTAP↑

promotion

lncRNA FOXD2-AS1↑/ FOXM1↑

Human osteosarcoma cell

[221]

METTL14↑

inhibition

caspase-3↑

Human osteosarcoma cell

[222]

ALKBH5↑、YTHDF2

promotion

lncRNA PVT1↑

Human osteosarcoma cell

[223]

ALKBH5↑YTHDF1

inhibition

YAP↓

Human osteosarcoma cell

[224]

ALKBH5↑YTHDF2

inhibition

miR-181b-1↑/ YAP↓

Human osteosarcoma cell

[224]

YTHDC1↑

promotion

LDHA↑、PFKM↑

Human osteosarcoma cell

[225]

YTHDF3↑

promotion

PGK1↑

Human osteosarcoma cell

[226]

METTL3↑

promotion

LEF1↑/ Wnt/β-catenin↑

Human osteosarcoma cell

[227]

FTO↑

promotion

DACT1↓/ Wnt/β-catenin↑

Human osteosarcoma cell

[228]

ALKBH5↑、

YTHDF2

inhibition

SOCS3↓/JAK2/ STAT3↓

Human osteosarcoma cell

[229]

METTL16↑

promotion

VPS33B↓/PI3K/AKT↑

Human osteosarcoma cell

[230]

WTAP↑

promotion

HMBOX1↓/PI3K/AKT↑

Human osteosarcoma cell

[231]

YTHDC1↑

promotion

PDPK1↑/ AKT/mTOR↑

Human osteosarcoma cell

[232]

Multiple myeloma

METTL3↑

promotion

THRAP3↑、RBM25↑、USP4↑、BZW2↑

Human MM cell lines H929

[233, 234]

METTL3↑

promotion

miR-182-5p↑/CAMK2N1↓, miR-27a-3p↑, YY1↑

Human MM cell lines H929

[235, 236]

WTAP↑、YTHDF2

inhibition

NDUFS6↓/ oxidative phosphorylation↓

Human MM cell lines

[237]

ALKBH5↑

promotion

lncRNA SNHG15↑/SETD2↑

Human MM cell lines

[238]

ALKBH5↑

promotion

TRAF1↑/NF-κB↑、MAPK↑

Human MM cell lines

[239]

FTO↑、YTHDF2

promotion

SOD2↓, HSF1↑

Human MM cell lines

[24, 240]

FTO↑

promotion

WNT7B↑/ Wnt/β-catenin↑

Human MM cell lines

[241]

HNRNPA2B1↑

promotion

ILF3↑、TLR4↑/ PI3K-AKT↑

Human MM cell lines

[242, 243]

hnRNPA2B1↑

promotion

miR-92a-2-5p↑/ IRF8↓/ NFATc1↑,

miR-373-3p↑/ Runx2↓

Human MM cell lines

[244]

YTHDF2↑

promotion

EGR1↓/ CDK2-cyclinE1↑

Human MM cell lines

[245]

YTHDF2↑

promotion

STAT5A↓/ MAP2K2/ p -ERK↑

Human MM cell lines

[246]

Metastatic bone tumors

metastatic prostate cancer

promotion

m⁶A-lncRNA NEAT1-1↑/ CYCLINL1/CDK19↑/

p-RNPII ser2↑/ Runx2↑

Human prostate cancer cell

[247]

METTL3↑、IGF2BP2

promotion

lncRNA PCAT6↑/ IGF1R↑

Human prostate cancer cell

[249]

METTL3↑、RBM3

inhibition

CTNNB1↓/Wnt/β-catenin↓

Human prostate cancer cell

[250]

Metastatic hepatocellular carcinoma

METTL3↑、YTHDF1

promotion

ANLN↑/KIF2C↑/mTORC1↑/RANKL↑

Human hepatocellular carcinoma cell

[251]

Metastatic breast cancer

YTHDF2↑

lncRNA FGF14-AS2↓/ eIF4E/eIF4G↑、p-eIF4E↑/ Runx2↑/ RANKL↑

Human breast cancer cell

[252]