Skip to main content
Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Glucagon-like peptide-1: a new potential regulator for mesenchymal stem cells in the treatment of type 2 diabetes mellitus and its complication

Fig. 2

Mechanisms of GLP-1 regulates MSCs differentiation

GLP-1 promotes osteogenic differentiation of MSCs through the Wnt and BMP signaling pathways and increases the migration of BMSCs to the bone surface through M2 macrophage polarization. GLP-1 promotes the differentiation of preadipocytes into small adipocytes and avoids hypertrophy of mature adipocytes through the Wnt, MAPK/ERK and PI3K/AKT signaling pathways, and promotes white adipose browning through increased expression of Nos, NPs, STAT1, and SIRT1. GLP-1 increases insulin and C-peptide expression by promoting the differentiation of MSCs into IPCs and facilitating the cellular development of IPCs

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512