Table 1 The information of clinicaltrials.gov about different types of MSCs (MSC) treat DM mellitus
From: A meta-analysis on application and prospect of cell therapy in the treatment of diabetes mellitus
ID | Disease | Age | Type of cell | Num | Interventions | Efficacy |
|---|---|---|---|---|---|---|
NCT02940418 | Type 1 DM | 18–35 | Allo ASCs | 20 | injected | efficacy |
NCT02893306 | Type 1 DM | 18 or older, | Allo BMSCs | 10 | IV | efficacy |
NCT05595681 | Foot ulcers | 40–75 | Allo ASCs | 30 | / | efficacy |
NCT04466007 | Limb Ischemia | 40–90 | Allo ASCs | 90 | IV | unknow |
NCT04869761 | Chronic Kidney | 30–80 | Allo ASCs | 40 | intravenous | no AE |
NCT02384018 | Type 1 DM | more than 18 | Auto BMSCs | 3 | portal vein | efficacy |
NCT03920397 | Type 1 DM | 16–35 | Allo ASCs | 30 | Infusion | efficacy |
NCT03840343 | Type 2 DM | 45–75 | Auto ASCs | 2 | IA | efficacy |
NCT03259217 | Foot ulcers | / | Auto ASCs | 40 | / | 50% efficacy |
NCT01257776 | Limb Ischemia | 18–85 | Auto ASCs | 33 | IA | no AE |
NCT05308836 | Type 1 DM | / | Auto ASCs | 10 | IV | unknow |
NCT02831075 | Foot ulcers | 18–80 | Allo ASCs | 240 | reinfection | efficacy |
NCT03865394 | Foot ulcers | more than 18 | Allo ASCs | 46 | cover fibrin gel | efficacy |
NCT03183726 | Foot ulcers | 18–80 | Allo ASCs | 4 | / | unknow |
NCT02387749 | Neuropathy | 18–45 | Auto BMSCs | 10 | / | efficacy |
NCT01142050 | Type 2 DM | 18–75 | Auto BMSCs | 24 | intravenously | efficacy |
NCT03754465 | Foot ulcers | 18–80 | Allo ASCs | 56 | / | efficacy |
NCT04497805 | Foot ulcers | 18–80 | Allo ASCs | 64 | / | efficacy |
NCT01686139 | Foot ulcers | 18–81 | Allogeneic BMSCs | 12 | injected | no AE |
NCT02796079 | Type 1/2 DM | 18–80 | Auto BMSCs | 240 | injected | efficacy |
NCT03370874 | Foot ulcers | 18–75 | Allo ASCs | 150 | / | efficacy |
NCT03343782 | Type 2 DM | more than 18 | Auto BMSCs | 30 | intravenously | efficacy |
NCT03509870 | Foot ulcers | 18–80 | Allogeneic BMSCs | 2 | / | no AE |
NCT01759823 | Type 2 DM | 30–70 | Auto BMSCs | 30 | injected | efficacy |
NCT02585622 | Type 2 DM | 40–85 | Allogeneic BMSCs | 48 | intravenously | no AE |
NCT03751735 | ED | 25–70 | Allo UCMSCs | 9 | injected | efficacy |
NCT02945449 | ED | 25–70 | Allo UCMSCs | 9 | injected | efficacy |
NCT03288571 | Nephropathy | 35–70 | Allo UCMSCs | 20 | injected | efficacy |
NCT03361631 | Type 1 DM | 18–50 | Auto BMSCs | 13 | ICI | efficacy |
NCT04569409 | Foot ulcers | 19–75 | Allo ASCs | 104 | / | efficacy |
NCT04078308 | Type 1 DM | 8–40 | Auto BMSCs | 20 | IV | no AE |
NCT03276312 | Foot ulcers | more than 18 | Auto ASCs | 112 | injected | efficacy |
NCT03973827 | Type 1 DM | 18–41 | Allo UCMSCs | 15 | infusion | efficacy |
NCT01068951 | Type 1 DM | 18–40 | Auto BMSCs | 20 | intravenously | efficacy |
NCT01065337 | Limb Ischemia | 18–80 | Auto BMSCs | 30 | injections | efficacy |
NCT01143168 | Type 1 DM | 18–50 | Auto BMSCs | 24 | intravenously | no AE |
NCT04125329 | Nephropathy | 18–60 | Allo UCMSCs | 15 | injection | no AE |
NCT01157403 | Type 1 DM | 10–40 | Auto BMSCs | 80 | intravenously | efficacy |
NCT01219465 | Type 1 DM | 3–35 | Allo UCMSCs | 50 | intravenously | efficacy |
NCT03325322 | Chronic Kidney | 40–80 | Allo ASCs | 30 | / | efficacy |
NCT04441658 | Type 2 DM | 30–75 | Allo UCMSCs | 30 | intravenously | efficacy |
NCT04216849 | Nephropathy | 30–70 | Allo UCMSCs | 54 | intravenously | unknow |
NCT03943940 | Type 2 DM | 18–70 | Auto BMMNCs and Allo UCMSCs | 60 | intravenous | unknow |
NCT04501341 | Type 2 DM | 30–60 | Auto BMSCs | 15 | blood vessels | efficacy |
NCT02886884 | ED | 21–90 | Allo ASCs | 16 | IV | no AE |
NCT03484741 | Type 1 DM | 18–45 | Auto BMSCs | 15 | IV | efficacy |
NCT02304588 | Foot ulcers | 30–78 | Auto BMSCs | 20 | injected | efficacy |
NCT05783115 | Foot ulcers | 35–80 | Auto BMSCs | 46 | / | efficacy |
NCT01322789 | Type 1 DM | 12–35 | Auto BMSCs | 10 | IV | efficacy |
NCT01374854 | Type 1 DM | 18–40 | Allo UCMSCs | 44 | infused | efficacy |
NCT04776239 | ED | more than 18 | Allo BMSCs | 30 | IV | efficacy |
NCT01719640 | Type 2 DM | 40–65 | Auto BMSCs | 22 | infusion | efficacy |
NCT02057211 | Type 1 DM | 18–40 | Auto BMSCs | 10 | / | efficacy |
NCT02763423 | Type 1 DM | 12–35 | Allo UCMSCs | 30 | IV | efficacy |
NCT00646724 | Type 1 DM | 18–60 | Allo UCMSCs | 30 | cotransplantation | efficacy |
NCT02834858 | VC | 18–80 | Allo UCMSCs | 240 | injection | efficacy |
NCT04562025 | Nephropathy | 30–65 | Auto UCMSCs and Allo UCMSCs | 38 | intravenously | no AE |
NCT04972890 | ED | 18–65 | Allo UCMSCs | 12 | injection | efficacy |
NCT02579148 | Type 1/2 DM | 20–65 | Allo UCMSCs | / | ICI | efficacy |
NCT00955669 | Limb Ischemia | 40–70 | Auto BMSCs | 40 | IM | unknow |
NCT05061030 | Type 1 DM | 7–21 | Allo UCMSCs | 66 | intravenously | efficacy |
NCT01216865 | Foot ulcers | 18–75 | Allo UCMSCs | 50 | Muscular injection | unknow |
NCT03406585 | Type 1 DM | 18–40 | Allo UCMSCs | 24 | infusion | efficacy |
NCT04061746 | Type 1 DM | 18–30 | Allo UCMSCs | 60 | IV | efficacy |
NCT02302599 | Type 2 DM | 20–65 | Allo UCMSCs | 103 | Infusion | efficacy |
NCT02619877 | Foot ulcers | 18–80 | Allo ASCs | 59 | / | no AE |
NCT03183804 | Foot ulcers | 18–80 | Allo ASCs | 54 | / | no AE |
NCT03248466 | Foot ulcers | 20–70 | Auto BMSCs | 60 | / | efficacy |
NCT05507697 | Neuropathy | 18–55 | Allo UCMSCs | 42 | injection | efficacy |
NCT03912480 | Type 1 DM | 25–70 | Auto BMSCs | 24 | Injection | efficacy |
NCT00690066 | Type 1 DM | 12–35 | Allo ASCs | 63 | IV | unknow |
NCT01954147 | Type 2 DM | 35–65 | Allo UCMSCs | 100 | / | unknow |
NCT04464213 | Foot ulcers | 18–75 | Auto PMSCs | 43 | / | efficacy |
NCT05003908 | Type 1/2 DM | / | Auto PMSCs | 20 | IV | efficacy |
NCT01496339 | Type 1 DM | 18–75 | Auto BMSCs | 50 | IV | unknow |
NCT02286128 | Type 2 DM | more than 18 | Auto BMSCs | 2 | / | efficacy |
NCT01413035 | Type 2 DM | 18–80 | Allo UCMSCs and Auto PMSCs | 30 | / | efficacy |
NCT04104451 | Foot ulcers | more than 18 | Allo UCMSCs | 16 | / | efficacy |
NCT02943486 | Foot ulcers | 40–80 | Auto BMSCs | 51 | Intradermic | efficacy |
NCT02745808 | Type 1/2 DM | 20–65 | Allo UCMSCs | 30 | ICI | efficacy |
NCT02138331 | Type 1 DM | 18–60 | Allo UCBMSCs | 20 | IV | efficacy |
NCT04642911 | Type 2 DM | / | Auto BMSCs | 91 | / | efficacy |
NCT02672280 | Foot ulcers | 18–70 | Allo UCBMSCs | 30 | / | no AE |