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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Mesenchymal stem cells protect the integrity of the alveolar epithelial barrier through extracellular vesicles by inhibiting MAPK-mediated necroptosis

Fig. 4

MenSCs inhibit MAPK signaling and necroptosis in LPS-induced ALI. (A,B) Western blot analysis of the phosphorylation of JNK, ERK, NF-κB p65, RIP1, and RIP3 and the phosphorylation of MLKL in the lung tissue of ALI mice. (C) The localization of RIP1, pMLKL in the mouse lung was determined on the last day of the experiment via immunofluorescence staining. Scale bar = 100 μm. (D,E) Western blot analysis of the phosphorylation of JNK, ERK, RIP1, and RIP3 and the phosphorylation of MLKL in A549 cells treated with LPS and MenSCs

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Stem Cell Research & Therapy

ISSN: 1757-6512