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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Mesenchymal stem cells protect the integrity of the alveolar epithelial barrier through extracellular vesicles by inhibiting MAPK-mediated necroptosis

Fig. 5

MenSC-EVs alleviate LPS-induced ALI and inhibit the MAPK/necroptosis signaling. (A) Schematic representation of the mouse model established in this study. PBS, LPS (4 mg/kg), and MenSC-EV (200 µg) were intratracheally administered to the mice. (B) Hematoxylin and eosin (H&E)-stained images of lungs. (C) Lung injury score. (D) Destructive index (DI). (E-K) Relative mRNA expression of inflammatory factors in the lungs of mice administered MenSC-EVs in the presence of LPS (4 mg/kg) was detected via qRT‒PCR

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Stem Cell Research & Therapy

ISSN: 1757-6512