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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Mesenchymal stem cells protect the integrity of the alveolar epithelial barrier through extracellular vesicles by inhibiting MAPK-mediated necroptosis

Fig. 7

MenSC-EVs alleviate LPS-induced alveolar epithelial cell dysfunction by inhibiting necroptosis. (A) The expression of p-MLKL, RIP1, RIP3, E-cadherin, Claudin-1, Occludin and ZO-1 was detected via Western blotting. (B) Immunofluorescence staining analysis of the localization of Occludin, and ZO-1 in A549 cell. (C) Western blot analysis of p-MLKL, RIP1, RIP3 and the tight junction markers E-cadherin, Occludin, Claudin-1, and ZO-1 in A549 cells treated with MenSC-EVs and the necroptosis inhibitor Nec-1. (D) Western blot analysis of p-MLKL, RIP1, RIP3 and the tight junction markers E-cadherin, Occludin, Claudin-1, and ZO-1 in A549 cells treated with MenSC-EVs and the necroptosis inhibitor GSK872

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Stem Cell Research & Therapy

ISSN: 1757-6512