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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Mesenchymal stem cells protect the integrity of the alveolar epithelial barrier through extracellular vesicles by inhibiting MAPK-mediated necroptosis

Fig. 8

MenSC-EVs alleviate LPS-induced alveolar epithelial cell dysfunction by inhibiting MAPK-mediated necroptosis. (A) Western blot analysis of p-JNK, p-MLKL, RIP1, RIP3 and the tight junction markers E-cadherin, Occludin, Claudin-1, and ZO-1 in A549 cell treated with MenSC-EVs and the JNK inhibitor SP600125. (B) Western blot analysis of p-ERK, p-MLKL, RIP1, RIP3 and the tight junction markers E-cadherin, Occludin, Claudin-1, and ZO-1 in A549 cell treated with MenSC-EVs and the ERK inhibitor U0126. (C) Schematic model of the efficacy and mechanism of MenSC-EVs on the lung inflammation and epithelial barrier damages in the treatment of ALI

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Stem Cell Research & Therapy

ISSN: 1757-6512