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Figure 4 | Stem Cell Research & Therapy

Figure 4

From: Overexpression of Bcl-2 promotes survival and differentiation of neuroepithelial stem cells after transplantation into rat aganglionic colon

Figure 4

Bcl-2 overexpression enhances the differentiation to PGP9.5-positive neurons of transplanted cells. Representative pictures of the (A) control group and (B) Bcl-2 group in cross-sections of colon 8 weeks post transplantation. Grafted neuroepithelial stem cells are shown in blue. Protein gene product 9.5 (PGP9.5) immunoreactivity is indicated in green. Glial fibrillary acidic protein immunoreactivity is indicated in red. LM, longitudinal muscle; CM, circular muscle. Scale bar = 200 μm. (C) Ratio of PGP9.5-positive cells versus 4',6-diamidino-2-phenylindole (DAPI)-labeled cells was counted. Bcl-2 overexpression increased the ratio of PGP9.5-positive cells. *Significant difference compared with control group (P < 0.05, n = 6 for each group).

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Stem Cell Research & Therapy

ISSN: 1757-6512