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  1. Parkinson´s disease (PD), the second most common neurodegenerative disease in the world, is characterized by the death or impairment of dopaminergic neurons (DAn) in the substantia nigra pars compacta and dopa...

    Authors: Anna Nelke, Silvia García-López, Javier R. Caso and Marta P. Pereira
    Citation: Stem Cell Research & Therapy 2024 15:356
    Content type: Research Published on:

  2. Burn injuries are serious injuries that have a big impact on a person’s health and can even cause death. Incurring severe burns can incite an immune response and inflammation within the body, alongside metabol...

    Authors: Tasaduq Manzoor, Nida Farooq, Arushi Sharma, Parvaiz A. Shiekh, Amreena Hassan, Lateef Ahmad Dar, Junaid Nazir, Meena Godha, Faheem A. Sheikh, Mudasir Bashir Gugjoo, Sahar Saleem and Syed Mudasir Ahmad
    Citation: Stem Cell Research & Therapy 2024 15:355
    Content type: Review Published on:

  3. Acute coronary syndromes, such as myocardial infarction (MI), lack effective therapies beyond heart transplantation, which is often hindered by donor scarcity and postoperative complications. Human induced plu...

    Authors: Xi Jiang, Xin Lian, Kun Wei, Jie Zhang, Kaihua Yu, Haoming Li, Haichun Ma, Yin Cai and Lei Pang
    Citation: Stem Cell Research & Therapy 2024 15:354
    Content type: Review Published on:

  4. Concentrated Growth Factor (CGF), rich in CD34 + stem cells, is widely used in treatments for androgenetic alopecia and skin rejuvenation due to its immune-modulating properties. Psoriasis, a chronic inflammat...

    Authors: Qin Xiao, Weifang Chu, Jing Guo, Jin Gao, Wei Yao, Minghuan Huang, Yongzhou Lu, Qiannan Xu and Nan Xu
    Citation: Stem Cell Research & Therapy 2024 15:353
    Content type: Research Published on:

  5. Chronic Limb Threatening Ischemia (CLTI) is a challenging clinical problem associated with high morbidity and mortality. Endovascular interventions have been the cornerstone of treatment whenever possible. It ...

    Authors: Sanjay Desai, Digvijay Sharma, Rajesh Srinivas, Venugopal Balaji, Vijay Thakore, Varinder Singh Bedi, Ravul Jindal, Amarnath Sugumaran, Senthilnathan Mohanasundaram, Jaideep Gogtay, Pawan Kumar Gupta, Aniruddha Bhuiyan and Gnaneswar Atturu
    Citation: Stem Cell Research & Therapy 2024 15:352
    Content type: Review Published on:

  6. Mesenchymal stromal cells (MSCs) are recognized for their potential in regenerative medicine, attributed to their multipotent differentiation capabilities and immunomodulatory properties. Despite this potentia...

    Authors: Nour Ebrahim, Nikolay Kondratyev, Alexander Artyuhov, Alexei Timofeev, Nadya Gurskaya, Alexey Andrianov, Roman Izrailov, Egor Volchkov, Tatyana Dyuzheva, Elena Kopantseva, Ekaterina Kiseleva, Vera Golimbet and Erdem Dashinimaev
    Citation: Stem Cell Research & Therapy 2024 15:351
    Content type: Research Published on:

  7. The histone-lysine N-methyltransferase SMYD1, which is specific to striated muscle, plays a crucial role in regulating early heart development. Its deficiency has been linked to the occurrence of congenital heart...

    Authors: Yun Chang, Rui Bai, Yongshuai Zhang, Wen-jing Lu, Shuhong Ma, Min Zhu, Feng Lan and Youxu Jiang
    Citation: Stem Cell Research & Therapy 2024 15:350
    Content type: Research Published on:

  8. The inflammatory microenvironment plays an essential role in bone healing after fracture. The signaling lymphocytic activation molecule family (SLAMF) members deeply participate in inflammatory response and ma...

    Authors: Yibo Wang, Kai Hang, Xiaoyong Wu, Li Ying, Zhongxiang Wang, Zemin Ling, Hao Hu, Zhijun Pan and Xuenong Zou
    Citation: Stem Cell Research & Therapy 2024 15:349
    Content type: Research Published on:

  9. Vasoactive intestinal peptide (VIP) is a neuronal peptide with prominent distribution along the enteric nervous system. While effects of VIP on intestinal motility, mucosal vasodilation, secretion, and mucosal...

    Authors: Tatiana Agibalova, Anneke Hempel, H. Carlo Maurer, Mohab Ragab, Anastasia Ermolova, Jessica Wieland, Caroline Waldherr Ávila de Melo, Fabian Heindl, Maximilian Giller, Julius Clemens Fischer, Markus Tschurtschenthaler, Birgit Kohnke-Ertel, Rupert Öllinger, Katja Steiger, Ihsan Ekin Demir, Dieter Saur…
    Citation: Stem Cell Research & Therapy 2024 15:348
    Content type: Research Published on:

  10. Quiescent self-renewal of leukemia stem cells (LSCs) and resistance to conventional chemotherapy are the main factors leading to relapse of acute myeloid leukemia (AML). Alpha-enolase (ENO1), a key glycolytic enz...

    Authors: Yun Tian, Jiafan Guo, Lipeng Mao, Zhixi Chen, Xingwei Zhang, Yangqiu Li, Yikai Zhang, Xianfeng Zha and Oscar Junhong Luo
    Citation: Stem Cell Research & Therapy 2024 15:347
    Content type: Research Published on:

  11. The metabolic patterns of human placental-derived mesenchymal stem cell (hP-MSC) treatment for primary sclerosing cholangitis (PSC) remain unclear, and therapeutic effects significantly vary due to individual ...

    Authors: Yingduo Yu, Qigu Yao, Deying Chen, Zhehua Zhang, Qiaoling Pan, Jiong Yu, Hongcui Cao, Liang Li and Lanjuan Li
    Citation: Stem Cell Research & Therapy 2024 15:346
    Content type: Research Published on:

  12. Extracellular vesicles (EVs) are cell-secreted membrane vesicles that have become a promising, natural nanoparticle system for delivering either naturally carried or exogenously loaded therapeutic molecules. A...

    Authors: Fan Tang, Tao Dong, Chengqian Zhou, Leon Deng, Hans B. Liu, Wenshen Wang, Guanshu Liu, Mingyao Ying and Pan P. Li
    Citation: Stem Cell Research & Therapy 2024 15:345
    Content type: Research Published on:

  13. Lung injury and pulmonary fibrosis (PF), frequently arising as sequelae of severe and acute lung disease, currently face a dearth of effective therapeutic potions. Mesenchymal stem cells (MSCs) with immunomodu...

    Authors: Dingyun Song, Zhongwen Li, Faguo Sun, Kaiwei Wu, Kan Zhang, Wenjing Liu, Kaidi Liu, Bin An, Zai Wang, Tiemei Zhao, Huaiyong Chen, Li Xiao, Liu Wang, Lixin Xie, Wei Li, Liang Peng…
    Citation: Stem Cell Research & Therapy 2024 15:344
    Content type: Research Published on:

  14. Ullrich congenital muscular dystrophy (UCMD) is caused by a deficiency in type 6 collagen (COL6) due to mutations in COL6A1, COL6A2, or COL6A3. COL6 deficiency alters the extracellular matrix structure and biomec...

    Authors: Megumi Yokomizo-Goto, Nana Takenaka-Ninagawa, Chengzhu Zhao, Clémence Kiho Bourgeois Yoshioka, Mayuho Miki, Souta Motoike, Yoshiko Inada, Denise Zujur, William Theoputra, Yonghui Jin, Junya Toguchida, Makoto Ikeya and Hidetoshi Sakurai
    Citation: Stem Cell Research & Therapy 2024 15:340
    Content type: Research Published on:

  15. Spinal cord injury (SCI) results in significant neural damage and inhibition of axonal regeneration due to an imbalanced microenvironment. Extensive evidence supports the efficacy of mesenchymal stem cell (MSC...

    Authors: Yifan Liu, Chenxi Zhao, Rong Zhang, Yilin Pang, Linquan Li and Shiqing Feng
    Citation: Stem Cell Research & Therapy 2024 15:343
    Content type: Review Published on:

  16. Orthodontic relapse (OR) occurs at a rate of over 70%. Retention is the current attempt at prevention, but it requires a considerable amount of time and cannot fully block OR. It’s imperative to find a safe an...

    Authors: Boyuan Peng, Lianhao Wang, Guangli Han and Yong Cheng
    Citation: Stem Cell Research & Therapy 2024 15:342
    Content type: Review Published on:

  17. The use of mobilizing agents for hematopoietic stem cell (HSC) transplantation is insufficient for an increasing number of patients. We previously reported lipid made endocannabinoid (eCB) ligands act on the h...

    Authors: Sevil Köse, Cem Varan, Selin Önen, Emirhan Nemutlu, Erem Bilensoy and Petek Korkusuz
    Citation: Stem Cell Research & Therapy 2024 15:341
    Content type: Research Published on:

  18. To investigate the long-term effects of combining bone marrow mesenchymal stem cells (MSCs) with mononuclear cells (MCs) in the treatment of type 2 diabetes mellitus (T2DM).

    Authors: Zhixian Wu, Shulin Huang, Shasha Li, Jinquan Cai, Lianghu Huang, Weizhen Wu, Jin Chen and Jianming Tan
    Citation: Stem Cell Research & Therapy 2024 15:339
    Content type: Research Published on:

  19. Human adipose-derived stromal/stem cells (hASCs) play important roles in regenerative medicine and numerous inflammatory diseases. However, their cellular heterogeneity limits the effectiveness of treatment. U...

    Authors: Yu Zhang, Mingxi Hua, Xuqing Ma, Weihong Li, Yuqi Cao, Xueya Han, Xiaowu Huang and Haiyan Zhang
    Citation: Stem Cell Research & Therapy 2024 15:338
    Content type: Research Published on:

  20. Mesenchymal stem cells (MSCs) are a type of cell capable of regulating the immune system, as well as exhibiting self-renewal and multi-lineage differentiation potential. Mesenchymal stem cells have emerged as ...

    Authors: Jialing Wang and Rui Li
    Citation: Stem Cell Research & Therapy 2024 15:337
    Content type: Review Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2024 15:372

  21. Obesity is accompanied by inflammation, which significantly affects the homeostasis of the immune microenvironment. Hematopoietic stem cells (HSCs), residing primarily in the bone marrow, play a vital role in ...

    Authors: Jinxiao Yan, Pan Zhang, Xiru Liu, Chengwei Pan, Guolin Shi, Penghui Ye, Xiaohang Zou, Xiang Li, Xinmin Zheng, Yu Liu and Hui Yang
    Citation: Stem Cell Research & Therapy 2024 15:336
    Content type: Research Published on:

  22. Patients with spinal cord injury (SCI) have permanent devastating motor and sensory disabilities. Secondary SCI is known for its complex progression and presents with sophisticated aberrant inflammation, vascu...

    Authors: Yueying Li, Wenqi Luo, Chuikai Meng, Kaiyuan Shi, Rui Gu and Shusen Cui
    Citation: Stem Cell Research & Therapy 2024 15:335
    Content type: Review Published on:

  23. The transplantation of periodontal ligament stem cells (PDLSCs) has been shown to enhance periodontal regeneration in animal models and clinical trials. However, it is not known whether PDLSCs are antibacteria...

    Authors: Jiayi You, Qian Zhang, Linjue Qian, Zihan Shi, Xinyue Wang, Lu Jia and Yang Xia
    Citation: Stem Cell Research & Therapy 2024 15:334
    Content type: Research Published on:

  24. Chimeric antigen receptor (CAR)-T therapy has emerged as a promising treatment for hematologic malignancies. However, cytopenia remains one of the most frequent and challenging adverse effects of this therapy.

    Authors: Yuan Xia, Li Wang, Xuxing Shen, Ying Xu, Wei Xu, Jianyong Li, Lei Fan and Lijuan Chen
    Citation: Stem Cell Research & Therapy 2024 15:333
    Content type: Research Published on:

  25. Human epithelium-derived stem cells and induced pluripotent stem cells (hiPSCs) possess the capability to support tooth formation and differentiate into functional enamel-secreting ameloblasts, making them pro...

    Authors: Chensheng Lin, Shiyu Liu, Minjun Huang, Yanding Zhang and Xuefeng Hu
    Citation: Stem Cell Research & Therapy 2024 15:332
    Content type: Research Published on:

  26. Mesenchymal stem/stromal cells (MSCs) have emerged as a promising tool in the field of regenerative medicine due to their unique therapeutic properties as they can differentiate into multiple cell types and ex...

    Authors: Cynthia Aylín García-Guerrero, Paloma Fuentes, María Jesús Araya, Farida Djouad, Patricia Luz-Crawford, Ana María Vega-Letter and Claudia Altamirano
    Citation: Stem Cell Research & Therapy 2024 15:331
    Content type: Review Published on:

  27. The human endometrium, lining the inner uterus, regenerates over 400 times uniquely during a woman’s reproductive life. Endometrial stem cells (eSCs) enrich the tissue, resulting in a dense vascular network, s...

    Authors: Priyanka Hilage, Apurva Birajdar, Tejesh Marsale, Dhanashree Patil, Ashwini Mane Patil, Gaurang Telang, Indumathi Somasundaram, Rakesh Kumar Sharma and Meghnad G. Joshi
    Citation: Stem Cell Research & Therapy 2024 15:330
    Content type: Research Published on:

  28. Fibrosis is a pathological scarring process characterized by persistent myofibroblast activation with excessive accumulation of extracellular matrix (ECM). Fibrotic disorders represent an increasing burden of ...

    Authors: Marianela Brizio, Mathieu Mancini, Maximilien Lora, Sydney Joy, Shirley Zhu, Benoit Brilland, Dieter P. Reinhardt, Dominique Farge, David Langlais and Inés Colmegna
    Citation: Stem Cell Research & Therapy 2024 15:329
    Content type: Research Published on:

  29. At present, fat transplantation is widely used in the plastic surgery industry, but the long-term preservation rate of transplanted fat decreases because of complications such as oil cysts due to the inability...

    Authors: Jiapeng Li, Tingting Guo, Ye Li, Qing Wang, Yuyang Du, Rou Li, Jiani Lin, Jiayue Fu, Xinyao Chen and Sai Luo
    Citation: Stem Cell Research & Therapy 2024 15:328
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2024 15:445

  30. The selection of suitable culture medium is critical for achieving good clinical outcomes in cell therapy. To support the commercial application of stem cell therapy, customized culture media not only need to ...

    Authors: Lan Zhao, Beibei Ni, Jinqing Li, Rui Liu, Qi Zhang, Zhuangbin Zheng, Wenjuan Yang, Wei Yu and Lijun Bi
    Citation: Stem Cell Research & Therapy 2024 15:327
    Content type: Research Published on:

  31. Cell therapy has emerged as a viable approach for treating damaged organs or tissues, particularly with advancements in stem cell research and regenerative medicine. The innovative technique of cell sheet engi...

    Authors: Danping Hu, Ce Gao, Jie Li, Pei Tong and Yi Sun
    Citation: Stem Cell Research & Therapy 2024 15:326
    Content type: Review Published on:

  32. The uncultured adipose-derived stromal vascular fraction (SVF), consisting of adipose-derived stromal cells (ADSCs), M2 macrophages (M2Φ) and others, has shown therapeutic potential against osteoarthritis (OA)...

    Authors: Yuma Onoi, Tomoyuki Matsumoto, Kensuke Anjiki, Shinya Hayashi, Naoki Nakano, Yuichi Kuroda, Masanori Tsubosaka, Tomoyuki Kamenaga, Kemmei Ikuta, Shotaro Tachibana, Yoshihito Suda, Kensuke Wada, Takuma Maeda, Akira Saitoh, Takafumi Hiranaka, Satoshi Sobajima…
    Citation: Stem Cell Research & Therapy 2024 15:325
    Content type: Research Published on:

  33. Chronic radiation dermatitis (CRD) is a late consequence of radiation with high incidence in patients receiving radiotherapy. Conventional therapies often yield unsatisfactory results. Therefore, this study ai...

    Authors: Yufan Zhu, Xu Liu, Xihang Chen and Yunjun Liao
    Citation: Stem Cell Research & Therapy 2024 15:324
    Content type: Research Published on:

  34. Myocardial infarction (MI) is a serious complication of coronary artery disease. This condition is common worldwide and has a profound impact on patients' lives and quality of life. Despite significant advance...

    Authors: Congwang Xu, Yuanyuan Xie and Bin Wang
    Citation: Stem Cell Research & Therapy 2024 15:323
    Content type: Review Published on:

  35. Single-cell omics technologies that profile genes (genomic and epigenomic) and determine the abundance of mRNA (transcriptomic), protein (proteomic and secretomic), lipids (lipidomic), and extracellular matrix...

    Authors: Giuliana Di Rocco, Angelo Trivisonno, Giovanni Trivisonno and Gabriele Toietta
    Citation: Stem Cell Research & Therapy 2024 15:322
    Content type: Review Published on:

  36. Despite the pivotal role of fat grafting in plastic, reconstructive, and aesthetic surgery, inconsistent survival rates of transplanted adipose tissue, primarily due to early ischemic and hypoxic insults, rema...

    Authors: Haoran Li, Zhengyao Li, Xiaoyu Zhang, Yan Lin, Tongtong Zhang, Leijuan Gan and Dali Mu
    Citation: Stem Cell Research & Therapy 2024 15:321
    Content type: Research Published on:

  37. Although liver transplantation (LT) is an effective strategy for end-stage liver diseases, the shortage of donor organs and the immune rejection hinder its widespread implementation in clinical practice. Mesen...

    Authors: Fuli Wen, Guokai Yang, Saihua Yu, Haiyan Liu, Naishun Liao and Zhengfang Liu
    Citation: Stem Cell Research & Therapy 2024 15:320
    Content type: Review Published on:

  38. Hematopoietic stem cells (HSCs) have emerged as one of the most therapeutically significant adult stem cells, paving way for a range of novel curative regimens over decades. HSCs are transplanted, either direc...

    Authors: Prathibha Babu Chandraprabha and Saravanabhavan Thangavel
    Citation: Stem Cell Research & Therapy 2024 15:319
    Content type: Commentary Published on:

  39. Fibroblast cells have the ability to improve skin conditions through regenerative medicine and cell-based therapies. The purpose of this scoping review is to assess the contribution of fibroblast cells to skin...

    Authors: Maryam Rahnama, Navid Ghasemzadeh, Yaser Ebrahimi and Ali Golchin
    Citation: Stem Cell Research & Therapy 2024 15:318
    Content type: Review Published on:

  40. Ex vivo haematopoietic stem/progenitor cell (HSPCs) expansion constitutes an important area of research, and has the potential to improve access to umbilical cord blood (UCB) as a source of stem cells for haem...

    Authors: Juanita Mellet, Candice L. Hendricks, Voula Stivaktas, Chrisna Durandt, Melvin A. Ambele and Michael S. Pepper
    Citation: Stem Cell Research & Therapy 2024 15:317
    Content type: Research Published on:

  41. Coronavirus disease 2019 (COVID-19) has created a global pandemic with significant morbidity and mortality. SARS-CoV-2 primarily infects the lungs and is associated with various organ complications. Therapeuti...

    Authors: Hajer A. Al Saihati, Arigue A. Dessouky, Rabab F. Salim, Islam Elgohary, Mohamed El-Sherbiny, Fares E. M. Ali, Mahmoud M. A. Moustafa, Dalia Shaheen, Nicholas Robert Forsyth, Omnia A. Badr and Nesrine Ebrahim
    Citation: Stem Cell Research & Therapy 2024 15:316
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2024 15:368

  42. Liver fibrosis can progress to end-stage cirrhosis and liver cancer. Mesenchymal stem cells (MSCs) were considered the most promising therapeutic strategy, but most of the MSCs injected intravenously tradition...

    Authors: Shanshan Li, Xufeng Fu, Junfeng Wang, Hongju Yang, Dan Wang, Xudong Dong, Yanchao Duan, Hong Wang, Yaping Yan and Wei Si
    Citation: Stem Cell Research & Therapy 2024 15:315
    Content type: Research Published on:

  43. Traumatic brain injury (TBI) is a major cause of disability and mortality worldwide. However, existing treatments still face numerous clinical challenges. Building on our prior research showing peripheral nerv...

    Authors: Hae Eun Shin, Won-Jin Lee, Kwang-Sook Park, Yerin Yu, Gyubin Kim, Eun Ji Roh, Byeong Gwan Song, Joon-Hyuk Jung, Kwangrae Cho, Young-hu Ha, Young-Il Yang and Inbo Han
    Citation: Stem Cell Research & Therapy 2024 15:314
    Content type: Research Published on:

  44. Duchenne muscular dystrophy (DMD) is an incurable neuromuscular disease leading to progressive skeletal muscle weakness and fatigue. Cell transplantation in murine models has shown promise in supplementing the...

    Authors: Clémence Kiho Bourgeois Yoshioka, Nana Takenaka-Ninagawa, Megumi Goto, Mayuho Miki, Daiki Watanabe, Masamichi Yamamoto, Tomoki Aoyama and Hidetoshi Sakurai
    Citation: Stem Cell Research & Therapy 2024 15:313
    Content type: Research Published on:

  46. Mesenchymal stem cells (MSCs) have shown a positive effect on Osteoarthritis (OA), but the efficacy is still not significant in clinical. Conventional two-dimensional (2D) monolayer culture method is prone to ...

    Authors: Qiang Fu, Mei Han, Xiaoyu Dai, Ruian Lu, Enjie Deng, Xuemei Shen, Feng Ou, Yongguang Pu, Xueqin Xie, Kang Liu, Yuanshan Gan and Dong Li
    Citation: Stem Cell Research & Therapy 2024 15:311
    Content type: Research Published on:

  47. Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), can undergo erythroid differentiation, offering a potentially invaluable resource...

    Authors: Hao Yan, Ruge Zang, Tiantian Cui, Yiming Liu, Biao Zhang, Lingpin Zhao, Hongyu Li, Juannian Zhou, Haiyang Wang, Quan Zeng, Lei Xu, Yuqi Zhou, Xuetao Pei, Jiafei Xi and Wen Yue
    Citation: Stem Cell Research & Therapy 2024 15:310
    Content type: Research Published on:

  48. Idiopathic pulmonary fibrosis (IPF) is an age-related disease featured with abnormal fibrotic response and compromised lung function. Cellular senescence is now considered as an essential driving mechanism for...

    Authors: Yuxin Liu, Jie Ji, Shudan Zheng, Ai Wei, Dongmei Li, Bin Shi, Xiaodong Han and Xiang Chen
    Citation: Stem Cell Research & Therapy 2024 15:309
    Content type: Research Published on:

  49. Articular cartilage degeneration can result from injury, age, or arthritis, causing significant joint pain and disability without surgical intervention. Currently, the only FDA cell-based therapy for articular...

    Authors: Ching Ann Tee, Daniel Ninio Roxby, Rashidah Othman, Vinitha Denslin, Kiesar Sideeq Bhat, Zheng Yang, Jongyoon Han, Lisa Tucker-Kellogg and Laurie A. Boyer
    Citation: Stem Cell Research & Therapy 2024 15:308
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2024 15:403

  50. Eosinophilic granulomatosis with polyangiitis (EGPA), a rare but life-threatening systemic vasculitis, is distinguished by marked eosinophilia and presents with diverse symptoms, including asthma, cutaneous pu...

    Authors: Hui Wang, Qian Zhang, Sensen Wu, Dikang Pan, Yachan Ning, Cong Wang, Jianming Guo and Yongquan Gu
    Citation: Stem Cell Research & Therapy 2024 15:307
    Content type: Short report Published on:
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Stem Cell Research & Therapy

ISSN: 1757-6512